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Medical Journals

Molecular Hydrogen has been found to have therapeutic effects on 8 of the 10 leading causes of death in the US.
 

This is very exciting news! A vital component of getting hydrogen into your cells is the water quality. It is very important to have finely filtered water to take the hydrogen to your Mitochondria (located within the nucleus of each cell that produces your cellular energy). Hydrogen benefits the Mitochondria by removing oxidative damage and protecting your cells from further damage. Mitochondria can be damaged by the ingestion of pharmaceuticals, chemicals and other pollutants such as microplastics in our water, air, food and even clothing. The Hydrogen is able to reach the Mitochondria to repair it, but the water you are consuming is extremely important. The World Health Organization (WHO) did a world-side study and found 83 % of ALL drinking water around the world now contains Microplastics.

Filtration of our water becomes vitally important. Combine your Hydrogen with the purest and best filtration possible...The Ion Thrive Hydro 3+ Water machine generates a high level of Hydrogen and filters out pollutants down to .001 micron! Choose your filtered water carefully! 

Hydrogen-rich water for improvements of mood, anxiety, and autonomic nerve function in daily life

Health and a vibrant life are sought by everyone. To improve quality of life (QOL), maintain a healthy state, and prevent various diseases, evaluations of the effects of potentially QOL-increasing factors are important. Chronic oxidative stress and inflammation cause deteriorations in central nervous system function, leading to low QOL. In healthy individuals, aging, job stress, and cognitive load over several hours also induce increases in oxidative stress, suggesting that preventing the accumulation of oxidative stress caused by daily stress and daily work contributes to maintaining QOL and ameliorating the effects of aging. Hydrogen has anti-oxidant activity and can prevent inflammation, and may thus contribute to improve QOL. The present study aimed to investigate the effects of drinking hydrogen-rich water (HRW) on the QOL of adult volunteers using psychophysiological tests, including questionnaires and tests of autonomic nerve function and cognitive function. In this double-blinded, placebo-controlled study with a two-way crossover design, 26 volunteers…”

Watanabe, Yasuyoshi, Kei Mizuno, Akihirot Sasaki, Kyoko Ebisu, Kanako Tajima, Osami Kajimoto, Junzo Nojima, Hirohiko Kuratsune, and Hiroshi Hori. "Hydrogen-rich Water for Improvements of Mood, Anxiety, and Autonomic Nerve Function in Daily Life." Medical Gas Research 7, no. 4 (January 22, 2018): 247-55. doi:10.4103/2045- 9912.222448

MOLECULAR HYDROGEN THERAPEUTIC CLINICAL STUDIES AND RESEARCH

1) Hydrogen-rich water for improvements of mood, anxiety, and autonomic nerve function in daily life

Health and a vibrant life are sought by everyone. To improve quality of life (QOL), maintain a healthy state, and prevent various diseases, evaluations of the effects of potentially QOL-increasing factors are important. Chronic oxidative stress and inflammation cause deteriorations in central nervous system function, leading to low QOL. In healthy individuals, aging, job stress, and cognitive load over several hours also induce increases in oxidative stress, suggesting that preventing the accumulation of oxidative stress caused by daily stress and daily work contributes to maintaining QOL and ameliorating the effects of aging. Hydrogen has anti-oxidant activity and can prevent inflammation, and may thus contribute to improve QOL. The present study aimed to investigate the effects of drinking hydrogen-rich water (HRW) on the QOL of adult volunteers using psychophysiological tests, including questionnaires and tests of autonomic nerve function and cognitive function. In this double-blinded, placebo-controlled study with a two-way crossover design, 26 volunteers…”

Watanabe, Yasuyoshi, Kei Mizuno, Akihirot Sasaki, Kyoko Ebisu, Kanako Tajima, Osami Kajimoto, Junzo Nojima, Hirohiko Kuratsune, and Hiroshi Hori. "Hydrogen-rich Water for Improvements of Mood, Anxiety, and Autonomic Nerve Function in Daily Life." Medical Gas Research 7, no. 4 (January 22, 2018): 247-55. doi:10.4103/2045- 9912.222448

 

2) Recent Progress Toward Hydrogen Medicine: Potential of Molecular Hydrogen for Preventive and Therapeutic Applications

“Oxidative stress arises from the strong cellular oxidizing potential of excess reactive oxygen species (ROS).. Persistent oxidative stress is one of the major causes of most lifestyle related diseases, cancer and the aging process. Acute oxidative stress arises from a variety of situations, including ischemia reperfusion…[and] directly causes serious damage to tissues. Despite the clinical importance of oxidative damage, antioxidants have been of limited therapeutic success. H2 as a number of advantages as a potential antioxidant. H2 rapidly diffuses into tissues and cells, and it is mild enough neither to disturb metabolic reactions nor to affect reactive oxygen species (ROS) that function in cell signaling, thereby, there should be little adverse effects of consuming H2…the biological effects of H2 have been confirmed by the publication of more than 38 diseases, physiological states and clinical tests in leading biological/medical journals, and several groups have started clinical examinations. H2 shows not only effects against oxidative stress, but also various anti-inflammatory and anti-allergic effects. H2 regulates various gene expressions and protein-phosphorylation…”

Ohta, Shigeo. "Recent Progress Toward Hydrogen Medicine: Potential of Molecular Hydrogen for Preventive and Therapeutic Applications." Current Pharmaceutical Design 17, no. 22 (July 2011): 2241-252. Accessed January 31, 2019. doi:10.2174/138161211797052664.

 

3) Effects of drinking hydrogen-rich water on the quality of life of patients treated with radiotherapy for liver tumors

“Cancer patients receiving radiotherapy often experience fatigue and impaired quality of life (QOL). Many side effects of radiotherapy are believed to be associated with increased oxidative stress and inflammation due to the generation of reactive oxygen species during radiotherapy. Hydrogen can be administered as a therapeutic medical gas, has antioxidant properties, and reduces inflammation in tissues. A randomized, placebo-controlled study was performed to evaluate the effects of drinking hydrogen-rich water on 49 patients receiving radiotherapy for malignant liver tumors. The concentration of derivatives of reactive oxidative metabolites and biological antioxidant power in the peripheral blood were assessed. The consumption of hydrogen-rich water for 6 weeks reduced reactive oxygen metabolites in the blood and maintained blood oxidation potential. QOL scores during radiotherapy were significantly improved in patients treated with hydrogen-rich water compared to patients receiving placebo water. There was no difference in tumor response to radiotherapy between the two groups. Daily consumption of hydrogen-rich water is a potentially novel, therapeutic strategy for improving QOL after radiation exposure. Consumption of hydrogen-rich water reduces the biological reaction to radiation-induced oxidative stress without compromising anti-tumor effects.

Kang, Ki-Mun, Young-Nam Kang, Ihil-Bong Choi, Yeunhwa Gu, Tomohiro Kawamura, Yoshiya Toyoda, and Atsunori Nakao. "Effects of Drinking Hydrogen-rich Water on the Quality of Life of Patients Treated with Radiotherapy for Liver Tumors." Medical Gas Research 1, no. 1 (June 7, 2011): 11. doi:10.1186/2045-9912-1-11.

 

4) Molecular Hydrogen as a preventative and therapeutic medical gas: initiation, development and potential of hydrogen medicine.

“Molecular hydrogen (H2) has been accepted to be an inert and nonfunctional molecule in our body. We have turned this concept by demonstrating that H2 reacts with strong oxidants such as hydroxyl radical in cells, and proposed its potential for preventative and therapeutic applications. H2 has a number of advantages exhibiting extensive effects: H2 rapidly diffuses into tissues and cells, and its mild enough neither to disturb metabolic redox reactions nor affect signaling reactive oxygen species; therefore, there should be no or little adverse effects of H2. ..The numerous publications on its biological and medical benefits revealed that H2 reduces oxidative stress not only by direct reactions with strong oxidants, but also indirectly by regulating various gene expressions. Moreover, by regulating the gene expressions, H2 functions as an anti-inflammatory and anti-apoptotic, and stimulates energy [for] metabolism…Owing to its great efficacy and lack of adverse effects H2 has promising potential for clinical use against many diseases.”

Ohta, Shigeo. "Molecular Hydrogen as a Preventive and Therapeutic Medical Gas: Initiation, Development and Potential of Hydrogen Medicine." Pharmacology & Therapeutics 144, no. 1 (April 24, 2014): 1-11. Accessed January 29, 2019. doi:10.1016/j.pharmthera.2014.04.006.

 
 

5) The evolution of molecular hydrogen: a noteworthy potential therapy with clinical significance.

“Studies on molecular hydrogen have evolved tremendously from its humble beginnings and have continued to change throughout the years. Hydrogen is extremely unique since it has the capability to act at the cellular level. Hydrogen is qualified to cross the blood brain barrier, to enter the mitochondria, and even has the ability to translocate to the nucleus under certain conditions…previous studies have shown that hydrogen exerts antioxidant, antiapoptotic, anti-inflammatory, and cytoprotective properties that are beneficial to the cell. This review article seeks to delve and comprehensively analyze research and experiments that alludes to molecular hydrogen being a novel therapeutic treatment that medicine desperately needs.”

Dixon, Brandon J., Jiping Tang, and John H. Zhang. "The Evolution of Molecular Hydrogen: A Noteworthy Potential Therapy with Clinical Significance." Medical Gas Research 3, no. 1 (May 16, 2013): 10. doi:10.1186/2045-9912-3-10.

 

6) Inhaled hydrogen gas therapy for prevention of noise-induced hearing loss through reducing reactive oxygen species

“Reactive oxygen species (ROS) that form in the inner ear play an important role in noise-induced hearing loss (NIHL). Recent studies have revealed that molecular hydrogen (H2) has great potential for reducing ROS. In this study, we examined the potential of hydrogen gas to protect against NIHL. We tested this hypothesis in guinea pigs with 0.5%, 1.0% and 1.5% H2 inhalation in air for 5 h a day after noise exposure, for five consecutive days. All animals underwent measurements for auditory brainstem response after the noise exposure. While strong immunoreactivities against 8-OHdG were observed of the non-treated group, the H2-treated group showed decreased immunoreactivity for 8-OHdG. These findings strongly suggest that inhaled hydrogen gas protects against NIHL.”

Kurioka, Takaomi, Takeshi Matsunobu, Yasushi Satoh, Katsuki Niwa, and Akihiro Shiotani. "Inhaled Hydrogen Gas Therapy for Prevention of Noise-induced Hearing Loss through Reducing Reactive Oxygen Species." Neuroscience Research 89 (September 6, 2014): 69-74. doi:10.1016/j.neures.2014.08.009.

 

7) Molecular Hydrogen: New Antioxidant and Anti-inflammatory Therapy for Rheumatoid Arthritis and Related Diseases

“Rheumatoid arthritis (RA) is a chronic inflammatory disease in which the progressive destruction of joint causes morbidity. It is also associated with an increased risk of atherosclerosis, which can result in cardiovascular disease and mortality. The therapeutic goal is to control the systemic inflammation to obtain not only the remission of symptoms, but also improve general state of health. Although recent biologic immunosuppressive therapies targeting pro-inflammatory cytokines have spawned a paradigm shift regarding the prognosis of RA, these therapies possess inherent side effects. Also, early diagnosis of the disease remains confounded by uncertainty. While the mechanisms responsible for the onset of RA remain unclear, reactive oxygen species (ROS) play a significant role in the pathogenesis of RA. Rheumatoid arthritis (RA) is a chronic inflammatory disease that affects approximately 1% of the population. It is characterized by irreversible joint disorder accompanied by destruction of bone and cartilage, which causes serious morbidity. In addition, the chronic inflammation associated with RA can increase one’s risk of atherosclerosis, which is a significant cause of mortality with the cardiovascular failure. H2 is an inert gas present within the human body and is not classified as a medicine, but it has been shown to have therapeutic and diagnostic potential for RA as discussed here. The apparatus for creating H2-enriched water (over 5 ppm of H2) is already available commercially. The preventive effect of H2 may be shown by those populations who drink the high H2 water daily.”

Ishibashi, Toru. "Molecular Hydrogen: New Antioxidant and Anti-inflammatory Therapy for Rheumatoid Arthritis and Related Diseases." Current Pharmaceutical Design19, no. 35 (January 01, 2013): 6375-381. doi:10.2174/13816128113199990507. 

 

8) Molecular Hydrogen in Drinking Water Protects against Neurodegenerative Changes Induced by 

“Traumatic brain injury (TBI) in its various forms has emerged as a major problem for modern society. Acute TBI can transform into a chronic condition and be a risk factor for neurodegenerative diseases such as Alzheimer’s and Parkinson’s diseases, probably through induction of oxidative stress and neuroinflammation. Here, we examined the ability of the antioxidant molecular hydrogen given in drinking water (molecular hydrogen water; mHW) to alter the acute changes induced by controlled cortical impact (CCI), a commonly used experimental model of TBI...we found that mHW preserved or increased ATP levels and propose a new mechanism for mHW, that of ATP production through the Jagendorf reaction. These results show that molecular hydrogen given in drinking water reverses many of the sequelae of CCI and suggests that it could be an easily administered, highly effective treatment for TBI.”

Dohi, Kenji, Brian C. Kraemer, Michelle A. Erickson, Pamela J. Mcmillan, Andrej Kovac, Zuzana Flachbartova, Kim M. Hansen, Gul N. Shah, Nader Sheibani, Therese Salameh,
and William A. Banks. "Molecular Hydrogen in Drinking Water Protects against Neurodegenerative Changes Induced by Traumatic Brain Injury." PLoS ONE 9, no. 9

9) A review of experimental studies of hydrogen as a new therapeutic agent in emergency and critical care medicine  

“Hydrogen is the most abundant chemical element in the Universe, but is seldom regarded as a therapeutic agent. Recent evidence has shown that hydrogen is a potent antioxidative, antiapoptotic and anti-inflammatory agent and so may have potential medical applications in cells, tissues and organs...in July 2007 researchers from the Japan Medical University Institute of Geriatrics reported that inhaled hydrogen gas has anti-oxidant and anti-apoptotic properties that protect the brain against ischemia–reperfusion (I/R) injury and stroke by selectively reducing hydroxyl radicals (·OH) and ONOO− in cell-free systems. Accumulating evidence suggests that hydrogen can protect various cells, tissues and organs against oxidative injury. This review focuses on the findings of recent studies of the effects of hydrogen in different disease models in emergency and critical care medicine …”

Shen, Meihua, Hongying Zhang, Congjun Yu, Fan Wang, and Xuejun Sun. "A Review of Experimental Studies of Hydrogen as a New Therapeutic Agent in Emergency and Critical Care Medicine." Medical Gas Research 4, no. 1 (November 8, 2014): 17. doi:10.1186/2045-9912-4-17. 

 

10) Hydrogen as a Selective Antioxidant: A Review of Clinical and Experimental Studies  

“Oxidative stress is implicated in the pathogenesis of many diseases; however, currently used antioxidants have a high toxicity that constrains administration to a narrow window of therapeutic dosage. There is a clear need for more effective and safer antioxidants. Diatomic hydrogen (H2) was proposed as a novel antioxidant that selectively reduces levels of toxic reactive-oxygen species. Recently, many studies have reported that H2 (inhaled or orally ingested, typically as approximately 0.8 mM H2-saturated water), can exert beneficial effects in diverse animal models of ischaemia–reperfusion injury, and inflammatory and neurological disease. In the clinic, oral administration of H2-saturated water is reported to improve lipid and glucose metabolism in subjects with diabetes or impaired glucose tolerance; promising results have also been obtained in reducing inflammation in haemodialysis patients and treating metabolic syndrome. These studies suggest H2 has selective antioxidant properties, and can exert antiapoptotic, anti-inflammatory and antiallergy effects. “

Hong, Y., S. Chen, and J-M Zhang. "Hydrogen as a Selective Antioxidant: A Review of Clinical and Experimental Studies." Journal of International Medical Research 38, no. 6 (December 1, 2010): 1893-903. doi:10.1177/147323001003800602. 

 
 

11) The 2011 Medical Molecular Hydrogen Symposium: An inaugural symposium of the journal Medical Gas Research.

“Novel medical gases are expected to provide us with more effective therapeutic interventions and preventative medicine. In the past decades, there has been extraordinary, rapid growth in our knowledge of gaseous molecules, including nitric oxide, carbon monoxide, and hydrogen sulfide, which have been known to play important roles in biological systems. Additionally, since Dr. Shigeo Ohta’s group’s pioneering paper was published in the June 2007 Nature Magazine showing the potency of hydrogen as a therapeutic gas for oxidative stress-mediated diseases including cerebral infarction, basic and clinical hydrogen research has resurfaced. In Japan, the birthplace of hydrogen gas research, Dr. Ohta (Nippon Medical School), who is currently serving as an Associate Editor of Medical Gas Research, organized annual “Medical Molecular Hydrogen Research Meetings” in 2009 and 2010 to provide investigators with focused opportunities to share their rapid scientific progress. This report summarizes a brief description/history of the Hydrogen Research Meetings as well as key presentations/ oral abstracts delivered in the most recent symposium.”

Ohta, Shigeo, Atsunori Nakao, and Kinji Ohno. "The 2011 Medical Molecular Hydrogen Symposium: An Inaugural Symposium of the Journal Medical Gas Research." Medical Gas Research 1, no. 1 (June 7, 2011): 10. doi:10.1186/2045-9912-1-10.

 

12) Medication-induced mitochondrial damage and disease.

“Since the first mitochondrial dysfunction was described in the 1960s, the medicine has advanced in its understanding the role mitochondria play in health and disease. Damage to mitochondria is now understood to play a role in the pathogenesis of a wide range of seemingly unrelated disorders such as schizophrenia, bipolar disease, dementia, Alzheimer's disease, epilepsy, migraine headaches, strokes, neuropathic pain, Parkinson's disease, ataxia, transient ischemic attack, cardiomyopathy, coronary artery disease, chronic fatigue syndrome, fibromyalgia, retinitis pigmentosa, diabetes, hepatitis C, and primary biliary cirrhosis. Medications have now emerged as a major cause of mitochondrial damage, which may explain many adverse effects. All classes of psychotropic drugs have been documented to damage mitochondria, as have stain medications, analgesics such as acetaminophen, and many others. The most rational approach is to understand the mechanisms underlying mitochondrial damage for specific medications and attempt to counteract their deleterious effects with nutritional therapies. This article reviews our basic understanding of how mitochondria function and how medications damage mitochondria to create their occasionally fatal adverse effects.” 

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Neustadt, John, and Steve R. Pieczenik. "Medication-induced Mitochondrial Damage and Disease." Molecular Nutrition & Food Research 52, no. 7 (July 2008): 780-88. 

13) The Mitochondrial Basis of Aging

“A decline in mitochondrial quality and activity has been associated with normal aging and correlated with the development of a wide range of age-related diseases. Here, we review the evidence that a decline in mitochondria function contributes to aging. In particular, we discuss how mitochondria contribute to specific aspects of the aging process, including cellular senescence, chronic inflammation, and the age-dependent decline in stem cell activity. Signaling pathways regulating the mitochondrial unfolded protein response and mitophagy are also reviewed, with particular emphasis placed on how these pathways might, in turn, regulate longevity. Taken together, these observations suggest that mitochondria influence or regulate a number of key aspects of aging and suggest that strategies directed at improving mitochondrial quality and function might have far-reaching beneficial effects. “

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Sun, Nuo, Richard J. Youle, and Toren Finkel. "The Mitochondrial Basis of Aging." Molecular Cell61, no. 5 (March 3, 2016): 654-66. doi:10.1016/j.molcel.2016.01.028.

 
 

14) A novel bioactive haemodialysis system using dissolved dihydrogen (H2) produced by water electrolysis: a clinical trial

“Chronic inflammation in haemodialysis (HD) patients indicates a poor prognosis. However, therapeutic approaches are limited. Hydrogen gas (H2) ameliorates oxidative and inflammatory injuries to organs in animal models. We developed an HD system using a dialysis solution with high levels of dissolved H2 and examined the clinical effects. During the study period, no adverse clinical signs or symptoms were observed. A significant decrease in systolic blood pressure (SBP) before and after dialysis was observed during the study, and a significant number of patients achieved SBP<140mmHg after HD (baseline, 21%;6 months, 62%; P<0.05). Changes in dialysis parameters were minimal, while significant decreases in levels of plasma monocyte chemoattractant protein 1 (P<0.01) and myeloperoxidase (P<0.05) were identified…Accumulating evidence suggests that enhanced oxidative stress and inflammation in patients on haemodialysis (HD) play crucial roles in increase risk of cardiovascular events and infectious diseases, which results in poor prognosis for the patient. Dihydrogen (H2) is an inert gas with no known side effects. Adding H2 to haemodialysis solutions ameliorated inflammatory reactions and improved BP control. This system could offer a novel therapeutic option for control of uraemia.

Nakayama, M., H. Nakano, H. Hamada, N. Itami, R. Nakazawa, and S. Ito. "A Novel Bioactive Haemodialysis System Using Dissolved Dihydrogen (H2) Produced by Water Electrolysis: A Clinical Trial." Nephrology Dialysis Transplantation 25, no. 9 (April 12, 2010): 3026-033. doi:10.1093/ndt/gfq196.

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